I've thought about the same thing. I think it could be done IF (and only if) you can use slayer weapons to still hit your 300% damage cap. To me, the biggest thing you loose without bushido is perfection. This has a dramatic impact on your damage output (and thus your life, stamina, and mana leeches).
The other thing to consider is your loss of critical hits (approx 1 in 5 or 6) with lightning strike and the max HCI on these hits. If you are running 45 HCI on your template with HLD (Mace & Shield glasses) then you will probably be ok. I run a sampire with 40 LMC and max weapon specials mana reduction and I can chain usually 3 or 4 AIs in a row before having to use LS for a hit or two and then back to AI chaining. That depends on your opponent and how much mana you leech. Without bushido, you could still use AIs, but you wouldn't be able to use LS. Usually some of my LS hits are crit hits so I can keep up the high damage output.
You would get the benefit of using a shield. There are some nice ones out there. On the opposite site, you have just negated your ability to use 2H weapons. You said you were a macer so that's probably not a big deal with your weapon selections. For swords in particular, that would be a deal breaker for me. My primary sampire is a macer and I use diamond maces, war axes (for AI), and black staffs (for whirlwind) almost exclusively.
The other things I use bushido for with my sampire are evasion and confidence. Those help me when I start to get into a bind. Of course, if you are running spirit speak you could just cast curse weapon and have added life leech to keep you alive. You would just have to be conservative with its use to keep your Karma high.
You're going to loose some versatility without perfection and have to haul a deep bag of slayer weapons, but I think it could be done to challenge a specific monster or places where all of the monsters are vulnerable to the same slayer. Oaks, the Tokuno Sleeping Dragon champ, and some of the UOML dungeons will probably be a bad idea due to the mixing of monster types.
-OBSIDIAN-
P.S. You would no longer have a "SAMpire" but then a "Vampire" dexxer. That actually sounds better to me.