I tried solo'ing her for the 1st time yesterday.
I got her down to about 1/3 life left and my virus scan decided to kick in. After a death due to the initial lag, I res'd up and once I got on her again, one of the mobs came over and I accidentally disarmed Medussa(was toggling between an Ornate Axe and a Radiant Scimitar)...needless to say, it all fell apart from there. I coudn't get my virus scan to stop so the lag was intense and she never would re-arm herself. I died about 10 times before I finally decided to call it quits. Damage pre-disarm was around 30-40...after disarm it went up to 45-55 and was almost constant.
Once I calmed down a bit, I changed my scan time and logged out for a few hours...hehe.
(this is with a suit with all 70's, 45 hci, 45dci, 182 stamina, 125 hp, 70+ mana, 40lmc, Slayer weapon, evasion/LS spam, and no Trinket)