In your original post, I think you were asking if it was going to be possible to do it while playing the game.
Who knows what may happen eventually, but for now that wouldn't work, because you'd have to close the game and restart it to benefit from the cleaned files.
However, one extra suggestion for speeding up the process...
I put a shortcut to the file on my desktop, so every day, after logging off I can just click on the shortcut and empty that file without having to go through a bunch of other folders to find it.
to make a shortcut:
Next time you go into the file, before you open the last folder with all the CC files in it,
RIGHT CLICK on it and select "Create Shortcut." It will place a shortcut icon in the file your're currently in. Just click & drag that icon onto your desk top. From then on, you can just double click the shortcut, and it'll take you directly to your CC folder for cleaning.
For the whiners
I know cleaning out the CC folder every few days is a slight inconvenience. But we've been begging for CC on this game since day one. It's roadblocks like this chache cleaning problem that have made it take so long to get it. I for one don't mind having to do a little maintenance if it means growth for the game.
This is an environment under construction - never ending. It's not that hard to clean the cache. If you don't like it, don't do it and stay away from CC and ignore items that don't load. We will one day not have to go through the process, I'm sure that some day they'll come up with a better way...but then there'll be some other issue to deal with. That's the nature of this always changing game.
If a mother had to give birth to a fully grown person who is educated, well-adjusted, ready to support themselves and never needing care...there would be no children born. You've got to change a few diapers, bandage scraped knees, & ground them for flunking algebra along the way.
OK...I feel better now