I need to confirm this, but my first experience with Despise showed me that it is unplayable if your ping is over 200 ms.
I'd lock every time while trying to move, and wouldn't be able to do anything but sit and watch my char be beaten to death by the enemies because I couldn't move, cast a single spell or command my pet.
I died at least 10 times today due to that. Commands felt unresponsive through all my runs there.
My ping was at 230ms and I was using the EC. There weren't many players running Despise at the time either.
Once I confirm this with a few more runs tonight, I will make a post at bug report.