Unless you are outfitted with no-name legendaries that also have luck you will be sacrificing stats for your killing ability. It depends on what you are fighting but if it's something big (let's say Dreadhorn as example) then it's probably best to use your normal suit and then swap over to your luck suit when it redlines. This way you will just need to have 70s resist and enough stats to stay alive while doing the last few hundred HP of damage.
You can also benefit from hunting in Fel (+1000 luck) and luck statue (depends on age but can be over 1000 luck) while using perfection (up to 1000). From those alone you can have 3k luck. Anything else is just icing on the cake.