I mentioned the NWN graphics. The reason being that you can zoom perspective from the style the UO has all the way in to first person with your mouse wheel. It would appeal to everyone!This.
Some of the basic UO functions are fairly dependent on the isometric viewpoint. I couldn't imagine attempting to bard two creatures in a WoW type view. As it is now you can easily target/etc.
As someone said, NWN graphics would be really nice, but part of the reason I still enjoy UO is the different game view. If you want a view like WoW, EQ, Lineage, etc, just go play those games.