Even if you could i'm not sure how you would. I can see how you could disable app's such as uoam and uoa but how would you disable the ability to use 3rd party speed enhancements, bandwidth regulators, caching devices. it sounds like a wonderful idea but i don't see how it is doable unless they revert to using something like punkbuster which wouldn't allot UO to run if certain applications were running, which keeps a list of applications from a database.
Secondly, even if it was pulled off i agree with some of the other posters, i think the game would take a critical hit as more people would run off then expected. They couldn't speed hack/script so they suck now so they aren't playing uo so it sucks because they say it does, they cant farm skills/loot/gold with easyuo and scripts anymore so they quit cause they can't make money or characters now. People have just gotten too spoiled with the apps to deal with not having them.