This is our family's basic set up. The way this system is used is to maximize macro keys and eliminate opening bags, searching for icons, or opening books, even being able to summon an item to my hand at the push of a button.
The icons that you do see are there basically because there aren't enough keys or it would become to difficult to remember all of them. I believe we have close to 50 macros when all is said and done.
The keyboard becomes kind of an instrument, where you set your fingers to the keys without having to look at them. This makes it possible to do anything that is needed without a distraction of having to open a bag or search for an item.
The full screen is definitely the best way to go because it is the most you can get out of what there is offered. I'm very happy with this set up. Being able to zoom in and out is what makes full screen affective.
I like to zoom in fully in small rooms, like when fighting RCs and turn up the music of the game. It is an amazing affect. The fact that I use targeting helps me to see and allows me to challenge myself by not being able to see everything and of course zooming out is a great advantage.
So, because of these possibilities plus the fact, with the touch of one button I can do many things and have so many buttons, i'm able to eliminate icons from the desktop.
One more thing, if I do need to open up my paperdoll or map or place lifebars, I am able to do it but I would much rather keep them closed unless I really need them.
I don't have any problems with movement, as far as what's on my screen.
Also, I am able to take all of the items that are in my backpack and move them to the bottom of the bag, like demon spell books, rune books, different talismans, different types of weapons, that I can now use a macro for rather than having to open my backpack. So, this opens up my backpack in a way because the items I have at the bottom of my bag I don't even see.
So, the ones I keep visible are the ones I don't have on a macro or placed into a square, this greatly helps with organizing.
There's probably alot more I could say about my set up but those are the basics, I think.