I found this great post from Tabin ....
Which ones are keyless?
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Here's what I recommend as a natural progression:
First. Make a crafter/imbuer. Loot as much magic junk as you can and drop them off in bags into your home. You need them to train imbuing. Eventually you will need 120 blacksmith, tailor, and imbuing for all your end game craftables.
What to hunt and why (from easiest to hardest). Anything medium difficult and above, I recommend bringing a friend or two the first few times.
EASY:
Tyball's shadow - get that Shroud of the Condemned. It isn't end game but its free stats. It's also fairly easy to get after you figure out how to get there.
Devourer of Souls - Go to the Abyss and farm this mini champ. Get your Animated Legs of Tinker.
Blackthorn Balrogs- get some black thorn artifacts. Get yourself a mace and shield helm. Fast gold and insanely fast respawn time.
MED DIFFICULTY:
Narvey - get a good lifeleech/manaleech/stam leech spider slayer. Solo it and learn the mechanics to solo it. Eventually you'll get a Tangle.
Champ Rat spawn. Get those PS scrolls. I hate getting raided though.
Champ Undead spawn. Get those PS scrolls. See above. I prefer this over the rat spawn. Less likely to get raided.
Medusa - Find a buddy. Learn the mechanics. Get the scales. Try soloing it. Now you know how to solo and earn a Slither. Slither has an awful drop rate though so good luck...I never got one.
HIGH DIFFICULTY:
Blackthorn captains - if you're good enough. They will always drop a blackthorn artifact. Some people prefer Paladins > Sampires for this.
Dreadhorn - get that Crimson Cinture. I hate those damn changelings but it gets easier the more you do it.
Chief Paroxysmus - Crimson Cinture and Swamp Dragon statue. It's a PAIN to get the keys.
Travesty - this is really tough. I did it for fun. It's not worth it to farm even after I figured out a secret mechanic to solo it "easier"
Corgul - get that sash.
END GAME:
Roof. Join a party. Learn the mechanics. Get gud and then try soloing. Here you'll get the best legendaries, minax sandals, jumu's sacred hide, and end game talismans.
Following this method, I was able to get most of my end game gear. I mostly played "self found" but I cheated by buying a really good legendary armor with high resistances.
Tabin of Atlantic
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