there are a few key strokes that are hard coded in to the interface and can't be changed by the user. Left Click while holding down the right mouse button triggers an auto follow your pointer, very useful if you don't want to hold your right mouse button and have a long way to walk, very annoying if you trigger it and don't intend to. As mentioned a quick right click stops it. There is also Alt+Left click a target, which triggers an auto follow of that target, very useful to tamers of non aggressive creatures, dangerous in some cases like PvP or taming a Greater Dragon.
To directly answer no that is one that can't be disabled.