I was under the impression that the amount and character of your karma has an effect on many of the chivalry spells. And the amount of good karma you've stacked up certainly can alter your experience doing some of the champion spawns. Your character's karma also affects his or her experience in the revamped Despise.
Karma affects both chivalry and necromancy spells, plus it's not a great idea to forget your thief has negative karma when wandering into areas such as Lakeshire
This is true. Although, when playing my pally I don't think I ever really "felt" the results of having higher karma and it's effect on my various spells. As for Champion spawns, that is a good point. Nothing like having your karma swing the wrong way when doing your first Oaks and all of sudden your getting whooped (thankfully someone told me NOT to kill everything in sight hehe). Despise is another example, if you wanted to experience the other side of the fight Exodus would be a good way to quickly swing your karma one way or the other.