Find a quiet spot (I tame them over by the coast) then pull one out on its own.
I tend to either stealth up and eat an orange petal to protect against cast poison, or I run in and drop an invis when I'm right beside the runey. That gives me a second or two before it realises what's going on and tries to eat my backside.
Be ready and equipped to cure that poison too. I try and work within reasonable distance of a healer *just in case*
But mostly I found if I just bolted off screen and healed up I was fine. I try and invis myself when I start taming.
I use a nightmare to beat up runeys, but they can be fast at healing back up once you start taming. But on the positive side, while they're healing themselves, they're not flamstriking
you That said I've always found them easy as long as I don't let them get a bite in. Or one of those [insert string of swear words] ninjas surfaces...
Wenchy