throwing works well with swords (for closer combat) Parry can negate the hci/dci penalties to holding a shield while throwing.
Imbuing is mostly standalone, you can have 50 itemid with it to see what an item will unravel to before unraveling. and like sweeney said, other craft skills help, for making a base item to imbue.
Mysticism is different with each spell, most spells get bonuses from evalint or imbuing. the Animated Weapon spell gets bonuses from tactics and anatomy i believe. My mystic is very powerful he runs 120 mystic 120 imbue 120 magery 120 evalint 120 med 120 spellweaving.
hope that helps