The spoilers and walkthrough are of great help. I did all the mini quest to complete the quest I just have to turn in at some point. The only thing I can add is this: At the winery use ctrl + shift to bring up object handles and double click the handle to create a scroll in your pack (also handy for raw ginsing). At the Yew Jail you have to go upstairs and go to the back, you just have to get close enough to double click the quest giver...maybe easier just to go around back the building than opening all the doors. Compassion Sage drop rate is bad, but you can insure it if you are on a weak toon so you don't lose it. "In The Face of Dragons" takes a while with 40 drakes 20 dragons and 5 greater dragons to kill and seems a little excessive. Killing an Unbound Energy Vortex is a simple enough task once you separate it from spawn which tends to drift around the area, Invis potions came in handy. Kill 50 trogs easy enough with quick respawn and repond slayer.
If the rune has no actual use as the saga continues, I will not feel the need to spend 2-3 hours to get another. It does give me an idea how the will bring about future quest which seems to flow fairly well so far.