Depends on what type of char your gonna use the Wep/Armor/Jewelry on. Like on my Samurai/Swordsman, i like Stamina Leech, considering he has 0.0 Real Chiv so he can't use Divine Fury, and i don't carry around tons of Total Refresh Pots. I would rather have Hit Lower Attack property on a weapon instead of Hit Lower Defense, considering the Mace & Shield Reading Glasses give HLD, and that HLA can help prevent you from being Disarmed.
Some of the best loot i've ever gotten has either been from the early Empty Bottle Quest at Heartwood (Now gives crappy loot), from a Strongbox, or Lady Mel when i switch to a Luck Suit just before she dies when on my Archer, for a total of 2748 Luck with Honor and 10th Anniversary Sculpture.
From the Empty Bottle Quest, i had gotten a Ring with FC 1/FCR 3/11% SDI/18% LRC/8% LMC, unfortunately i traded it for a Rune to a damn good Frostwood Tree and 5 Mill, hindsight is a pancake.
From the Strongbox Quest i have gotten both of my Necro/Mage's Jewelry, a Ring with +11 Necro/FC 1/FCR 3/17% LRC/11% Energy Resist. Bracelet has +8 Disco/+6 INT/FC 1/FCR 3/10% LRC. I have also gotten several good Ornate Axes. One my Samurai/Swordsman uses has 42% HLA/9% HCI/6% DCI/25% SSI/50% Dam Inc. One my GM LJ Swordsman uses has 44% Harm/47% Mana Leech/30% SSI/46% Dam Inc.
From Melisande, i have gotten a Repeating Crossbow with -21 Mage Wep/40% Energy Area/12% HCI/25% SSI/50% Dam Inc, i enhanced it Yew so it now has 17% HCI and 60% Dam Inc. A guildy of mine, Skoal, looted a uber godly Viking Sword off of her during his B-Day Mel's because of my Archer's Luck. It had like 40s Lightning/40s Stam Leech/14% HCI/30% SSI/50% Dam Inc. Some other good loot i have was probably from her, but can't remember for certain.